Lymphoscintigraphy via the targeting of macrophages with 99mTc-J001X poly-galactoside in a model of pyogranulomas developed in sheep lymph nodes
Identifieur interne : 000937 ( France/Analysis ); précédent : 000936; suivant : 000938Lymphoscintigraphy via the targeting of macrophages with 99mTc-J001X poly-galactoside in a model of pyogranulomas developed in sheep lymph nodes
Auteurs : Jean Christophe Pittet [France] ; Michel Pepin [France] ; Ge Rard Normier [France] ; Hanz Binz [France] ; Alain Le Pape [France]Source :
- Nuclear Medicine and Biology [ 0969-8051 ] ; 1995.
Abstract
Abstract: Lymphoscintigraphy usually involves labeled microparticles or colloids that distribute in the lymph flow. A new strategy for imaging pathological lymph nodes would be the targeting of macrophages recruited in these lesions. The potential for lymphoscintigraphy of the highly diffusible J001X acylated polygalactoside labeled with 99mTc was studied and compared to usual colloidal agents in a model of infectious granulomas developed in sheep. Scintigraphic and histological assessment of the specificity of targeting was performed using a MAb (OM1) raised against ovine macrophages taken as reference. This study has evidenced the ability of J001X specifically to image pathologic lymph nodes and more especially the second lymph node in the same chain with a significant scintigraphic contrast.
Url:
DOI: 10.1016/0969-8051(94)00100-X
Affiliations:
- France
- Centre-Val de Loire, Midi-Pyrénées, Occitanie (région administrative), Région Centre
- Labe`ge, Tours
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ISTEX:0C49B67AE3E465239C2B768DAEF69440F8DF4621Le document en format XML
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Fabre, 74160 St Julien-en Genevois</wicri:regionArea><wicri:noRegion>74160 St Julien-en Genevois</wicri:noRegion><wicri:noRegion>74160 St Julien-en Genevois</wicri:noRegion></affiliation></author><author><name sortKey="Le Pape, Alain" sort="Le Pape, Alain" uniqKey="Le Pape A" first="Alain" last="Le Pape">Alain Le Pape</name><affiliation></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Biophysique Cellulaire et RMN, Unite´INSERM U316, Faculte´de Me´decine, 2 bis boulevard Tonnelle´, 37032 Tours cedex</wicri:regionArea><wicri:noRegion>37032 Tours cedex</wicri:noRegion><wicri:noRegion>37032 Tours cedex</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Nuclear Medicine and Biology</title><title level="j" type="abbrev">NMB</title><idno type="ISSN">0969-8051</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995">1995</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="355">355</biblScope><biblScope unit="page" to="365">365</biblScope></imprint><idno type="ISSN">0969-8051</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0969-8051</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Lymphoscintigraphy usually involves labeled microparticles or colloids that distribute in the lymph flow. A new strategy for imaging pathological lymph nodes would be the targeting of macrophages recruited in these lesions. The potential for lymphoscintigraphy of the highly diffusible J001X acylated polygalactoside labeled with 99mTc was studied and compared to usual colloidal agents in a model of infectious granulomas developed in sheep. Scintigraphic and histological assessment of the specificity of targeting was performed using a MAb (OM1) raised against ovine macrophages taken as reference. This study has evidenced the ability of J001X specifically to image pathologic lymph nodes and more especially the second lymph node in the same chain with a significant scintigraphic contrast.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Centre-Val de Loire</li><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li><li>Région Centre</li></region><settlement><li>Labe`ge</li><li>Tours</li></settlement></list><tree><country name="France"><region name="Centre-Val de Loire"><name sortKey="Pittet, Jean Christophe" sort="Pittet, Jean Christophe" uniqKey="Pittet J" first="Jean Christophe" last="Pittet">Jean Christophe Pittet</name></region><name sortKey="Binz, Hanz" sort="Binz, Hanz" uniqKey="Binz H" first="Hanz" last="Binz">Hanz Binz</name><name sortKey="Le Pape, Alain" sort="Le Pape, Alain" uniqKey="Le Pape A" first="Alain" last="Le Pape">Alain Le Pape</name><name sortKey="Normier, Ge Rard" sort="Normier, Ge Rard" uniqKey="Normier G" first="Ge Rard" last="Normier">Ge Rard Normier</name><name sortKey="Pepin, Michel" sort="Pepin, Michel" uniqKey="Pepin M" first="Michel" last="Pepin">Michel Pepin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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